Drew Smyth, Owen Sylvain and Peter Vitello combined for 20 points during a 25-5 run in the third quarter, and the Tigers (2-3) withstood a fourth-quarter charge by the Capers (0-4) in Biddeford.
Sylvain finished with 18 points and Smyth scored 15 for Biddeford, which stretched a 25-19 halftime lead to 50-24 after three quarters.
Eli Smith led Cape Elizabeth with 23 points. JJ Schultzel added 11.