Ella Rice scored 11 of her 17 points in the second quarter, sparking a run they propelled the Ramblers (2-1) past the Seagulls (3-1) in Winthrop.
Rice made four 3-pointers, including three in the second quarter as Winthrop turned an 11-5 deficit into a 22-19 lead.
Madeline Wagner added 10 points and Kylee Mansir scored eight for the Ramblers.
OOB was paced by Tessa Ferguson with 19 points and Sarah Davis with 16.